Cargando…
The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT)
Retention in prevention of mother-to-child transmission (PMTCT) care is critical to prevent vertical HIV transmission and reduce morbidity and mortality of mother-infant pairs. We investigated whether weekly, interactive text-messaging improved 18-month postpartum retention in PMTCT care. This rando...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256764/ https://www.ncbi.nlm.nih.gov/pubmed/37296174 http://dx.doi.org/10.1038/s41598-023-35817-x |
_version_ | 1785057176352456704 |
---|---|
author | Nordberg, Björn van der Kop, Mia Liisa Mwangi, Winfred Mwangi, Jonathan Kaguiri, Eunice Chamorro de Angeles, Katrine J. Lester, Richard T. Gabriel, Erin E. Rautiainen, Susanne Awiti, Patricia Opondo Kågesten, Anna E. Were, Edwin Ekström, Anna Mia |
author_facet | Nordberg, Björn van der Kop, Mia Liisa Mwangi, Winfred Mwangi, Jonathan Kaguiri, Eunice Chamorro de Angeles, Katrine J. Lester, Richard T. Gabriel, Erin E. Rautiainen, Susanne Awiti, Patricia Opondo Kågesten, Anna E. Were, Edwin Ekström, Anna Mia |
author_sort | Nordberg, Björn |
collection | PubMed |
description | Retention in prevention of mother-to-child transmission (PMTCT) care is critical to prevent vertical HIV transmission and reduce morbidity and mortality of mother-infant pairs. We investigated whether weekly, interactive text-messaging improved 18-month postpartum retention in PMTCT care. This randomised, two-armed, parallel trial was conducted at six PMTCT clinics in western Kenya. Pregnant women with HIV at least 18 years of age with access to a mobile phone, able to text-message, or had somebody who could text on their behalf, were eligible. Participants were randomly assigned at a 1:1 ratio in block sizes of four to the intervention or control group. The intervention group received weekly text messages asking “How are you?” (“Mambo?” in Swahili) and were requested to respond within 48 h. Healthcare workers called women who indicated a problem or did not respond. The intervention was administered up to 24 months after delivery. Both groups received standard care. The primary outcome was retention in care at 18 months postpartum (i.e., clinic attendance 16–24 months after delivery based on data from patient files, patient registers and Kenya’s National AIDS and STI Control Programme database), which was analysed by intention-to-treat. Researchers and data collectors were masked to group assignment, while healthcare workers were not. Between June 25th, 2015, and July 5th, 2016, we randomly assigned 299 women to the intervention and 301 to standard care only. Follow-up concluded on July 26th, 2019. The proportion of women retained in PMTCT care at 18 months postpartum was not significantly different between the intervention (n = 210/299) and control groups (n = 207/301) (risk ratio 1.02, 95% confidence interval 0.92–1.14, p = 0.697). No adverse events related to the mobile phone intervention were reported. Weekly, interactive text-messaging was not associated with improved retention in PMTCT care at 18 months postpartum or linkage to care up to 30 months postpartum in this setting. (ISRCTN No. 98818734). |
format | Online Article Text |
id | pubmed-10256764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102567642023-06-11 The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT) Nordberg, Björn van der Kop, Mia Liisa Mwangi, Winfred Mwangi, Jonathan Kaguiri, Eunice Chamorro de Angeles, Katrine J. Lester, Richard T. Gabriel, Erin E. Rautiainen, Susanne Awiti, Patricia Opondo Kågesten, Anna E. Were, Edwin Ekström, Anna Mia Sci Rep Article Retention in prevention of mother-to-child transmission (PMTCT) care is critical to prevent vertical HIV transmission and reduce morbidity and mortality of mother-infant pairs. We investigated whether weekly, interactive text-messaging improved 18-month postpartum retention in PMTCT care. This randomised, two-armed, parallel trial was conducted at six PMTCT clinics in western Kenya. Pregnant women with HIV at least 18 years of age with access to a mobile phone, able to text-message, or had somebody who could text on their behalf, were eligible. Participants were randomly assigned at a 1:1 ratio in block sizes of four to the intervention or control group. The intervention group received weekly text messages asking “How are you?” (“Mambo?” in Swahili) and were requested to respond within 48 h. Healthcare workers called women who indicated a problem or did not respond. The intervention was administered up to 24 months after delivery. Both groups received standard care. The primary outcome was retention in care at 18 months postpartum (i.e., clinic attendance 16–24 months after delivery based on data from patient files, patient registers and Kenya’s National AIDS and STI Control Programme database), which was analysed by intention-to-treat. Researchers and data collectors were masked to group assignment, while healthcare workers were not. Between June 25th, 2015, and July 5th, 2016, we randomly assigned 299 women to the intervention and 301 to standard care only. Follow-up concluded on July 26th, 2019. The proportion of women retained in PMTCT care at 18 months postpartum was not significantly different between the intervention (n = 210/299) and control groups (n = 207/301) (risk ratio 1.02, 95% confidence interval 0.92–1.14, p = 0.697). No adverse events related to the mobile phone intervention were reported. Weekly, interactive text-messaging was not associated with improved retention in PMTCT care at 18 months postpartum or linkage to care up to 30 months postpartum in this setting. (ISRCTN No. 98818734). Nature Publishing Group UK 2023-06-09 /pmc/articles/PMC10256764/ /pubmed/37296174 http://dx.doi.org/10.1038/s41598-023-35817-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nordberg, Björn van der Kop, Mia Liisa Mwangi, Winfred Mwangi, Jonathan Kaguiri, Eunice Chamorro de Angeles, Katrine J. Lester, Richard T. Gabriel, Erin E. Rautiainen, Susanne Awiti, Patricia Opondo Kågesten, Anna E. Were, Edwin Ekström, Anna Mia The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT) |
title | The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT) |
title_full | The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT) |
title_fullStr | The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT) |
title_full_unstemmed | The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT) |
title_short | The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT) |
title_sort | effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of hiv care: a randomised controlled trial (weltel pmtct) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256764/ https://www.ncbi.nlm.nih.gov/pubmed/37296174 http://dx.doi.org/10.1038/s41598-023-35817-x |
work_keys_str_mv | AT nordbergbjorn theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT vanderkopmialiisa theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT mwangiwinfred theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT mwangijonathan theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT kaguirieunice theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT chamorrodeangeleskatrinej theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT lesterrichardt theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT gabrielerine theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT rautiainensusanne theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT awitipatriciaopondo theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT kagestenannae theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT wereedwin theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT ekstromannamia theeffectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT nordbergbjorn effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT vanderkopmialiisa effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT mwangiwinfred effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT mwangijonathan effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT kaguirieunice effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT chamorrodeangeleskatrinej effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT lesterrichardt effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT gabrielerine effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT rautiainensusanne effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT awitipatriciaopondo effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT kagestenannae effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT wereedwin effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct AT ekstromannamia effectofaninteractiveweeklytextmessaginginterventiononretentioninpreventionofmothertochildtransmissionofhivcarearandomisedcontrolledtrialweltelpmtct |