The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT)

Retention in prevention of mother-to-child transmission (PMTCT) care is critical to prevent vertical HIV transmission and reduce morbidity and mortality of mother-infant pairs. We investigated whether weekly, interactive text-messaging improved 18-month postpartum retention in PMTCT care. This rando...

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Autores principales: Nordberg, Björn, van der Kop, Mia Liisa, Mwangi, Winfred, Mwangi, Jonathan, Kaguiri, Eunice, Chamorro de Angeles, Katrine J., Lester, Richard T., Gabriel, Erin E., Rautiainen, Susanne, Awiti, Patricia Opondo, Kågesten, Anna E., Were, Edwin, Ekström, Anna Mia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256764/
https://www.ncbi.nlm.nih.gov/pubmed/37296174
http://dx.doi.org/10.1038/s41598-023-35817-x
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author Nordberg, Björn
van der Kop, Mia Liisa
Mwangi, Winfred
Mwangi, Jonathan
Kaguiri, Eunice
Chamorro de Angeles, Katrine J.
Lester, Richard T.
Gabriel, Erin E.
Rautiainen, Susanne
Awiti, Patricia Opondo
Kågesten, Anna E.
Were, Edwin
Ekström, Anna Mia
author_facet Nordberg, Björn
van der Kop, Mia Liisa
Mwangi, Winfred
Mwangi, Jonathan
Kaguiri, Eunice
Chamorro de Angeles, Katrine J.
Lester, Richard T.
Gabriel, Erin E.
Rautiainen, Susanne
Awiti, Patricia Opondo
Kågesten, Anna E.
Were, Edwin
Ekström, Anna Mia
author_sort Nordberg, Björn
collection PubMed
description Retention in prevention of mother-to-child transmission (PMTCT) care is critical to prevent vertical HIV transmission and reduce morbidity and mortality of mother-infant pairs. We investigated whether weekly, interactive text-messaging improved 18-month postpartum retention in PMTCT care. This randomised, two-armed, parallel trial was conducted at six PMTCT clinics in western Kenya. Pregnant women with HIV at least 18 years of age with access to a mobile phone, able to text-message, or had somebody who could text on their behalf, were eligible. Participants were randomly assigned at a 1:1 ratio in block sizes of four to the intervention or control group. The intervention group received weekly text messages asking “How are you?” (“Mambo?” in Swahili) and were requested to respond within 48 h. Healthcare workers called women who indicated a problem or did not respond. The intervention was administered up to 24 months after delivery. Both groups received standard care. The primary outcome was retention in care at 18 months postpartum (i.e., clinic attendance 16–24 months after delivery based on data from patient files, patient registers and Kenya’s National AIDS and STI Control Programme database), which was analysed by intention-to-treat. Researchers and data collectors were masked to group assignment, while healthcare workers were not. Between June 25th, 2015, and July 5th, 2016, we randomly assigned 299 women to the intervention and 301 to standard care only. Follow-up concluded on July 26th, 2019. The proportion of women retained in PMTCT care at 18 months postpartum was not significantly different between the intervention (n = 210/299) and control groups (n = 207/301) (risk ratio 1.02, 95% confidence interval 0.92–1.14, p = 0.697). No adverse events related to the mobile phone intervention were reported. Weekly, interactive text-messaging was not associated with improved retention in PMTCT care at 18 months postpartum or linkage to care up to 30 months postpartum in this setting. (ISRCTN No. 98818734).
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spelling pubmed-102567642023-06-11 The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT) Nordberg, Björn van der Kop, Mia Liisa Mwangi, Winfred Mwangi, Jonathan Kaguiri, Eunice Chamorro de Angeles, Katrine J. Lester, Richard T. Gabriel, Erin E. Rautiainen, Susanne Awiti, Patricia Opondo Kågesten, Anna E. Were, Edwin Ekström, Anna Mia Sci Rep Article Retention in prevention of mother-to-child transmission (PMTCT) care is critical to prevent vertical HIV transmission and reduce morbidity and mortality of mother-infant pairs. We investigated whether weekly, interactive text-messaging improved 18-month postpartum retention in PMTCT care. This randomised, two-armed, parallel trial was conducted at six PMTCT clinics in western Kenya. Pregnant women with HIV at least 18 years of age with access to a mobile phone, able to text-message, or had somebody who could text on their behalf, were eligible. Participants were randomly assigned at a 1:1 ratio in block sizes of four to the intervention or control group. The intervention group received weekly text messages asking “How are you?” (“Mambo?” in Swahili) and were requested to respond within 48 h. Healthcare workers called women who indicated a problem or did not respond. The intervention was administered up to 24 months after delivery. Both groups received standard care. The primary outcome was retention in care at 18 months postpartum (i.e., clinic attendance 16–24 months after delivery based on data from patient files, patient registers and Kenya’s National AIDS and STI Control Programme database), which was analysed by intention-to-treat. Researchers and data collectors were masked to group assignment, while healthcare workers were not. Between June 25th, 2015, and July 5th, 2016, we randomly assigned 299 women to the intervention and 301 to standard care only. Follow-up concluded on July 26th, 2019. The proportion of women retained in PMTCT care at 18 months postpartum was not significantly different between the intervention (n = 210/299) and control groups (n = 207/301) (risk ratio 1.02, 95% confidence interval 0.92–1.14, p = 0.697). No adverse events related to the mobile phone intervention were reported. Weekly, interactive text-messaging was not associated with improved retention in PMTCT care at 18 months postpartum or linkage to care up to 30 months postpartum in this setting. (ISRCTN No. 98818734). Nature Publishing Group UK 2023-06-09 /pmc/articles/PMC10256764/ /pubmed/37296174 http://dx.doi.org/10.1038/s41598-023-35817-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nordberg, Björn
van der Kop, Mia Liisa
Mwangi, Winfred
Mwangi, Jonathan
Kaguiri, Eunice
Chamorro de Angeles, Katrine J.
Lester, Richard T.
Gabriel, Erin E.
Rautiainen, Susanne
Awiti, Patricia Opondo
Kågesten, Anna E.
Were, Edwin
Ekström, Anna Mia
The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT)
title The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT)
title_full The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT)
title_fullStr The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT)
title_full_unstemmed The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT)
title_short The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT)
title_sort effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of hiv care: a randomised controlled trial (weltel pmtct)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256764/
https://www.ncbi.nlm.nih.gov/pubmed/37296174
http://dx.doi.org/10.1038/s41598-023-35817-x
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