Cargando…

Navoximod modulates local HSV-1 replication to reshape tumor immune microenvironment for enhanced immunotherapy via an injectable hydrogel

Oncolytic virotherapy can lead to tumor lysis and systemic anti-tumor immunity, but the therapeutic potential in humans is limited due to the impaired virus replication and the insufficient ability to overcome the immunosuppressive tumor microenvironment (TME). To solve the above problems, we identi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhuang, Qiuyu, Zhao, Binyu, Lin, Zhiwen, Liang, Yuzhi, Zhao, Qingfu, Wang, Yunhao, Liao, Naishun, Tu, Haibin, Zheng, Youshi, Chen, Hengkai, Zeng, Yongyi, Zhang, Da, Liu, Xiaolong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256817/ https://www.ncbi.nlm.nih.gov/pubmed/37296221 http://dx.doi.org/10.1038/s42003-023-04983-z

Ejemplares similares

Remodeling Tumor‐Associated Neutrophils to Enhance Dendritic Cell‐Based HCC Neoantigen Nano‐Vaccine Efficiency
por: Wang, Yunhao, et al.
Publicado: (2022)

Adipose tissue-derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabetic rats
por: Liao, Naishun, et al.
Publicado: (2017)

Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency in a mouse liver fibrosis model
por: Liao, Naishun, et al.
Publicado: (2020)

Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion
por: Liao, Naishun, et al.
Publicado: (2019)

Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor
por: Ma, Shuguang, et al.
Publicado: (2019)

Natural killer cells modified with a Gpc3 aptamer enhance adoptive immunotherapy for hepatocellular carcinoma
por: Zheng, Youshi, et al.
Publicado: (2023)

Systemic delivery of glycosylated-PEG-masked oncolytic virus enhances targeting of antitumor immuno-virotherapy and modulates T and NK cell infiltration
por: Liang, Yuzhi, et al.
Publicado: (2023)

Immunotherapy: Reshape the Tumor Immune Microenvironment
por: LV, Bingzhe, et al.
Publicado: (2022)

An injectable, in situ forming and NIR-responsive hydrogel persistently reshaping tumor microenvironment for efficient melanoma therapy
por: Zhang, Han, et al.
Publicado: (2023)

Regulated extravascular microenvironment via reversible thermosensitive hydrogel for inhibiting calcium influx and vasospasm
por: Zhao, Binfan, et al.
Publicado: (2022)

Reshaping the Pancreatic Cancer Microenvironment at Different Stages with Chemotherapy
por: Peng, Maozhen, et al.
Publicado: (2023)

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
por: Nayak-Kapoor, Asha, et al.
Publicado: (2018)

Highlights on the Role of KRAS Mutations in Reshaping the Microenvironment of Pancreatic Adenocarcinoma
por: Hafezi, Shirin, et al.
Publicado: (2021)

Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance
por: Zhang, Aiping, et al.
Publicado: (2022)

Histone lactylation regulates cancer progression by reshaping the tumor microenvironment
por: Qu, Junxing, et al.
Publicado: (2023)

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy
por: Xiong, Wenjun, et al.
Publicado: (2022)

P988: LACTATE RESHAPES TUMOR MICROENVIRONMENT AND METABOLIC PROFILE IN MYELOFIBROSIS
por: Giallongo, S., et al.
Publicado: (2022)

Reshaping the tumor microenvironment: The versatility of immunomodulatory drugs in B-cell neoplasms
por: Guo, Hao, et al.
Publicado: (2022)

Extracellular vesicles in hematological malignancies: EV-dence for reshaping the tumoral microenvironment
por: Van Morckhoven, David, et al.
Publicado: (2023)

PLEKHA4 is a novel prognostic biomarker that reshapes the tumor microenvironment in lower-grade glioma
por: Zhi, Wenqian, et al.
Publicado: (2023)

Multifunctional Nanoregulator Reshapes Immune Microenvironment and Enhances Immune Memory for Tumor Immunotherapy
por: Yu, Meng, et al.
Publicado: (2019)

Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
por: Song, Chanyoung, et al.
Publicado: (2019)

Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment
por: Wang, Wenyu, et al.
Publicado: (2020)

Cryoablation reshapes the immune microenvironment in the distal tumor and enhances the anti-tumor immunity
por: Wu, Ying, et al.
Publicado: (2022)

Beyond direct killing—novel cellular immunotherapeutic strategies to reshape the tumor microenvironment
por: Huynh, Duc, et al.
Publicado: (2022)

CRIP1 Reshapes the Gastric Cancer Microenvironment to Facilitate Development of Lymphatic Metastasis
por: Wu, Zhonghua, et al.
Publicado: (2023)

Vascular normalization: reshaping the tumor microenvironment and augmenting antitumor immunity for ovarian cancer
por: Yu, Ping, et al.
Publicado: (2023)

An olsalazine nanoneedle-embedded inulin hydrogel reshapes intestinal homeostasis in inflammatory bowel disease
por: Zhang, Zhuangzhuang, et al.
Publicado: (2023)

m(6)A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion
por: Cao, Xiaoxue, et al.
Publicado: (2023)

Phase I study of the indoleamine 2,3-dioxygenase 1 inhibitor navoximod (GDC-0919) as monotherapy and in combination with the PD-L1 inhibitor atezolizumab in Japanese patients with advanced solid tumours
por: Ebata, Takahiro, et al.
Publicado: (2019)

Nanomedicines targeting activation of STING to reshape tumor immune microenvironment and enhance immunotherapeutic efficacy
por: Chen, Shanshan, et al.
Publicado: (2023)

Reshaping tumor immune microenvironment by Epstein-Barr virus activation in the stroma of colorectal cancer
por: Park, Hyun Ju, et al.
Publicado: (2022)

Adjusting the dose of traditional drugs combined with immunotherapy: reshaping the immune microenvironment in lung cancer
por: Wang, Linlin, et al.
Publicado: (2023)

An intravenous anesthetic drug-propofol, influences the biological characteristics of malignant tumors and reshapes the tumor microenvironment: A narrative literature review
por: Zhou, Xueliang, et al.
Publicado: (2022)

Poly (dopamine) coated superparamagnetic iron oxide nanocluster for noninvasive labeling, tracking, and targeted delivery of adipose tissue-derived stem cells
por: Liao, Naishun, et al.
Publicado: (2016)

A Replication-Defective Herpes Simplex Virus (HSV)-2 Vaccine, HSV529, is Safe and Well-Tolerated in Adults with or without HSV Infection and Induces Significant HSV-2-Specific Antibody Responses in HSV Seronegative Individuals
por: Dropulic, Lesia, et al.
Publicado: (2017)

Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
por: Zhong, Fengyun, et al.
Publicado: (2023)

Harnessing the soil: reshaping the tumor microenvironment towards an antitumor immune state by low‐dose metformin
por: Lin, Yusheng, et al.
Publicado: (2021)

Exosome secretion from hypoxic cancer cells reshapes the tumor microenvironment and mediates drug resistance
por: To, Kenneth K. W., et al.
Publicado: (2022)

Prognostic value of cuproptosis-related genes signature and its impact on the reshaped immune microenvironment of glioma
por: Chen, Siliang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_piqjlod3c1ce6f3uhc52d6lije