Empowering drug off-target discovery with metabolic and structural analysis

Elucidating intracellular drug targets is a difficult problem. While machine learning analysis of omics data has been a promising approach, going from large-scale trends to specific targets remains a challenge. Here, we develop a hierarchic workflow to focus on specific targets based on analysis of...

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Detalles Bibliográficos
Autores principales: Chowdhury, Sourav, Zielinski, Daniel C., Dalldorf, Christopher, Rodrigues, Joao V., Palsson, Bernhard O., Shakhnovich, Eugene I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256842/
https://www.ncbi.nlm.nih.gov/pubmed/37296102
http://dx.doi.org/10.1038/s41467-023-38859-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256842/
https://www.ncbi.nlm.nih.gov/pubmed/37296102
http://dx.doi.org/10.1038/s41467-023-38859-x

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