Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation

G-quadruplexes (G4s) regulate DNA replication and gene transcription, and are enriched in promoters without fully appreciated functional relevance. Here we show high selection pressure on putative G4 (pG4) forming sequences in promoters through investigating genetic and genomic data. Analyses of 76,...

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Detalles Bibliográficos
Autores principales: Li, Guangyue, Su, Gongbo, Wang, Yunxuan, Wang, Wenmeng, Shi, Jinming, Li, Dangdang, Sui, Guangchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257653/
https://www.ncbi.nlm.nih.gov/pubmed/37301913
http://dx.doi.org/10.1038/s42003-023-05015-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257653/
https://www.ncbi.nlm.nih.gov/pubmed/37301913
http://dx.doi.org/10.1038/s42003-023-05015-6

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