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Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation
G-quadruplexes (G4s) regulate DNA replication and gene transcription, and are enriched in promoters without fully appreciated functional relevance. Here we show high selection pressure on putative G4 (pG4) forming sequences in promoters through investigating genetic and genomic data. Analyses of 76,...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257653/ https://www.ncbi.nlm.nih.gov/pubmed/37301913 http://dx.doi.org/10.1038/s42003-023-05015-6 |