Rare genetic variants impact muscle strength

Muscle strength is highly heritable and predictive for multiple adverse health outcomes including mortality. Here, we present a rare protein-coding variant association study in 340,319 individuals for hand grip strength, a proxy measure of muscle strength. We show that the exome-wide burden of rare...

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Detalles Bibliográficos
Autores principales: Huang, Yunfeng, Bodnar, Dora, Chen, Chia-Yen, Sanchez-Andrade, Gabriela, Sanderson, Mark, Shi, Jun, Meilleur, Katherine G., Hurles, Matthew E., Gerety, Sebastian S., Tsai, Ellen A., Runz, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257725/
https://www.ncbi.nlm.nih.gov/pubmed/37301943
http://dx.doi.org/10.1038/s41467-023-39247-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10257725/
https://www.ncbi.nlm.nih.gov/pubmed/37301943
http://dx.doi.org/10.1038/s41467-023-39247-1

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