Cargando…

Glucocorticoid-induced activation of NOX/ROS/NF-κB signaling in MSCs contributes to the development of GONFH

Background: This study aimed to investigate the pathogenic factors of glucocorticoids (GCs)-induced osteonecrosis of the femoral head (GONFH) and its underlying pathogenesis in vivo and in vitro. Methods: Radiographical (µCT) scanning, histopathological, immunohistochemical, reactive oxygen species...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Huihui, Zeng, Qinghe, Zou, Kaiao, Huang, Haipeng, Chen, Jiali, Wang, Pinger, Yuan, Wenhua, Xiao, Luwei, Tong, Peijian, Jin, Hongting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258081/ https://www.ncbi.nlm.nih.gov/pubmed/37306805 http://dx.doi.org/10.1007/s10495-023-01860-2

Ejemplares similares

Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response
por: Zeng, Qinghe, et al.
Publicado: (2023)

Chondroprotective Mechanism of Eucommia ulmoides Oliv.-Glycyrrhiza uralensis Fisch. Couplet Medicines in Knee Osteoarthritis via Experimental Study and Network Pharmacology Analysis
por: Wang, Pinger, et al.
Publicado: (2023)

Disruption of Col9a2 expression leads to defects in osteochondral homeostasis and osteoarthritis-like phenotype in mice
por: Dong, Rui, et al.
Publicado: (2023)

N-Butanol Extract of Modified You-Gui-Yin Attenuates Osteoclastogenesis and Ameliorates Osteoporosis by Inhibiting RANKL-Mediated NF-κB Signaling
por: Zeng, Qinghe, et al.
Publicado: (2022)

Osteoking Decelerates Cartilage Degeneration in DMM-Induced Osteoarthritic Mice Model Through TGF-β/smad-dependent Manner
por: Ling, Houfu, et al.
Publicado: (2021)

Is aquatic exercise more effective than land-based exercise for knee osteoarthritis?
por: Dong, Rui, et al.
Publicado: (2018)

Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis Via Activation of β-Catenin Signaling in Growth Plate Chondrocytes
por: Xu, Rui, et al.
Publicado: (2021)

Waterfall Forest Environment Regulates Chronic Stress via the NOX4/ROS/NF-κB Signaling Pathway
por: Zhu, Zixin, et al.
Publicado: (2021)

Elucidation of the Underlying Mechanism of Gujian Oral Liquid Acting on Osteoarthritis through Network Pharmacology, Molecular Docking, and Experiment
por: Wu, Congzi, et al.
Publicado: (2022)

Administration of erythropoietin prevents bone loss in osteonecrosis of the femoral head in mice
por: Xu, Taotao, et al.
Publicado: (2017)

Caffeic acid phenethyl ester suppresses monocyte adhesion to the endothelium by inhibiting NF-κB/NOX2-derived ROS signaling
por: Nakahara, Risa, et al.
Publicado: (2016)

Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway
por: Li, Jiameng, et al.
Publicado: (2021)

Col9a2 gene deletion accelerates the degeneration of intervertebral discs
por: Xu, Huihui, et al.
Publicado: (2022)

MSCs enhances the protective effects of valsartan on attenuating the doxorubicin-induced myocardial injury via AngII/NOX/ROS/MAPK signaling pathway
por: Cheng, Dong, et al.
Publicado: (2021)

Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway
por: Wang, Lili, et al.
Publicado: (2017)

Sodium butyrate enhances titanium nail osseointegration in ovariectomized rats by inhibiting the PKCα/NOX4/ROS/NF-κB pathways
por: Liu, Zhiyi, et al.
Publicado: (2023)

Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-κB Pathways
por: Feng, Chencheng, et al.
Publicado: (2017)

Corrigendum: Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway
por: Wang, Lili, et al.
Publicado: (2017)

Vasculoprotective effects of Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats
por: Sulistyowati, Erna, et al.
Publicado: (2019)

Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis
por: Fang, Liang, et al.
Publicado: (2020)

NOX- and ROS-Driven Hypertension in Elastin Insufficiency
por: Gavazzi, Gaëtan, et al.
Publicado: (2021)

NOX-like ROS production by glutathione reductase
por: Diaz, Julia M., et al.
Publicado: (2022)

NOX Dependent ROS Generation and Cell Metabolism
por: Pecchillo Cimmino, Tiziana, et al.
Publicado: (2023)

Pristimerin Inhibits MMP-9 Expression and Cell Migration Through Attenuating NOX/ROS-Dependent NF-κB Activation in Rat Brain Astrocytes Challenged with LPS
por: Yang, Chien-Chung, et al.
Publicado: (2020)

Ursolic acid ameliorates CCl4‐induced liver fibrosis through the NOXs/ROS pathway
por: Gan, Dakai, et al.
Publicado: (2018)

Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state
por: Trevelin, Silvia Cellone, et al.
Publicado: (2016)

The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NFκB-Dependent Manner
por: Helfinger, V., et al.
Publicado: (2019)

Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-β/Smad2 signaling in chondrocytes
por: Ge, Qinwen, et al.
Publicado: (2023)

Particulate matter induces inflammatory cytokine production via activation of NFκB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin
por: Ryu, Yea Seong, et al.
Publicado: (2018)

Activation of β‐catenin in Col2‐expressing chondrocytes leads to osteoarthritis‐like defects in hip joint
por: Xia, Chenjie, et al.
Publicado: (2019)

S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway
por: Yang, Guang, et al.
Publicado: (2020)

Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-κB Dependent and Independent Pathways: Protective Effects of Polyphenols
por: Ho, Chia-Chi, et al.
Publicado: (2021)

The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs
por: Jin, Hongting, et al.
Publicado: (2016)

Morroniside ameliorates inflammatory skeletal muscle atrophy via inhibiting canonical and non-canonical NF-κB and regulating protein synthesis/degradation
por: Yi, Xiangjiao, et al.
Publicado: (2022)

Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis
por: Xu, Shibing, et al.
Publicado: (2017)

Amygdalin Promotes Fracture Healing through TGF-β/Smad Signaling in Mesenchymal Stem Cells
por: Ying, Jun, et al.
Publicado: (2020)

Genome‐wide microRNA screening reveals miR‐582‐5p as a mesenchymal stem cell‐specific microRNA in subchondral bone of the human knee joint
por: Wang, Pinger, et al.
Publicado: (2019)

SAA1 increases NOX4/ROS production to promote LPS-induced inflammation in vascular smooth muscle cells through activating p38MAPK/NF-κB pathway
por: Yu, Mei-Hong, et al.
Publicado: (2019)

Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells
por: Sul, Ok-Joo, et al.
Publicado: (2021)

Impact of Nox5 Polymorphisms on Basal and Stimulus-Dependent ROS Generation
por: Wang, Yusi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9d1djv7jos6j4umtajcrhre6d7