The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes

IL-32 is a pro-inflammatory cytokine expressed by several types of cancer cells and immune cells. Currently, no treatment targeting IL-32 is available, and its intracellular and exosomal localization make IL-32 less accessible to drugs. We previously showed that hypoxia promotes IL-32 expression thr...

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Detalles Bibliográficos
Autores principales: Kastnes, Martin, Aass, Kristin Roseth, Bouma, Siri Anshushaug, Årseth, Charlotte, Zahoor, Muhammad, Yurchenko, Mariia, Standal, Therese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258340/
https://www.ncbi.nlm.nih.gov/pubmed/37313466
http://dx.doi.org/10.3389/fonc.2023.1197542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258340/
https://www.ncbi.nlm.nih.gov/pubmed/37313466
http://dx.doi.org/10.3389/fonc.2023.1197542

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