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SKP2 Contributes to AKT Activation by Ubiquitination Degradation of PHLPP1, Impedes Autophagy, and Facilitates the Survival of Thyroid Carcinoma

Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. Despite a good prognosis, approximately a quarter of PTC patients are likely to relapse. Previous reports suggest an association between S-phase kinase-associated protein 2 (SKP2) and the prognosis of thyroid cancer....

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Detalles Bibliográficos
Autores principales: Shao, Yuan, Ren, Wanli, Dai, Hao, Yang, Fangli, Li, Xiang, Zhang, Shaoqiang, Liu, Junsong, Yao, Xiaobao, Zhao, Qian, Sun, Xin, Zheng, Zhiwei, Xu, Chongwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258456/
https://www.ncbi.nlm.nih.gov/pubmed/36694914
http://dx.doi.org/10.14348/molcells.2022.2242