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Suboptimal Mitochondrial Activity Facilitates Nuclear Heat Shock Responses for Proteostasis and Genome Stability

Thermal stress induces dynamic changes in nuclear proteins and relevant physiology as a part of the heat shock response (HSR). However, how the nuclear HSR is fine-tuned for cellular homeostasis remains elusive. Here, we show that mitochondrial activity plays an important role in nuclear proteostasi...

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Detalles Bibliográficos
Autores principales: Park, Dongkeun, Yu, Youngim, Kim, Ji-hyung, Lee, Jongbin, Park, Jongmin, Hong, Kido, Seo, Jeong-Kon, Lim, Chunghun, Min, Kyung-Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258458/
https://www.ncbi.nlm.nih.gov/pubmed/37077029
http://dx.doi.org/10.14348/molcells.2023.2181