Site-selective radiolabeling using mushroom tyrosinase and the strain-promoted oxidation-controlled 1,2-quinone cycloaddition

We report the in vitro characterization and in vivo evaluation of a novel (89)Zr-labeled radioimmunoconjugate synthesized using a site-selective bioconjugation strategy based on the oxidation of tyrosinase residues exposed by the deglycosylation of the IgG and the subsequent strain-promoted oxidatio...

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Detalles Bibliográficos
Autores principales: Rodriguez, Cindy, Delaney, Samantha, Sebastiano, Joni, Sarrett, Samantha M., Cornejo, Mike A., Thau, Sarah, Hosny, Meena M., Zeglis, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258682/
https://www.ncbi.nlm.nih.gov/pubmed/37313000
http://dx.doi.org/10.1039/d3ra03486k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258682/
https://www.ncbi.nlm.nih.gov/pubmed/37313000
http://dx.doi.org/10.1039/d3ra03486k

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