To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide

[Image: see text] Membrane disruptive α-helical antimicrobial peptides (AMPs) offer an opportunity to address multidrug resistance; however, most AMPs are toxic and unstable in serum. These limitations can be partly overcome by introducing D-residues, which often confers protease resistance and redu...

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Detalles Bibliográficos
Autores principales: Personne, Hippolyte, Paschoud, Thierry, Fulgencio, Sofia, Baeriswyl, Stéphane, Köhler, Thilo, van Delden, Christian, Stocker, Achim, Javor, Sacha, Reymond, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258794/
https://www.ncbi.nlm.nih.gov/pubmed/37227046
http://dx.doi.org/10.1021/acs.jmedchem.3c00460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258794/
https://www.ncbi.nlm.nih.gov/pubmed/37227046
http://dx.doi.org/10.1021/acs.jmedchem.3c00460

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