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To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide
[Image: see text] Membrane disruptive α-helical antimicrobial peptides (AMPs) offer an opportunity to address multidrug resistance; however, most AMPs are toxic and unstable in serum. These limitations can be partly overcome by introducing D-residues, which often confers protease resistance and redu...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258794/ https://www.ncbi.nlm.nih.gov/pubmed/37227046 http://dx.doi.org/10.1021/acs.jmedchem.3c00460 |