Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases

[Image: see text] New derivatives of aminoglycosides with a side chain 1,2-aminoalcohol at the 5” position of ring III were designed, synthesized, and biologically evaluated. The novel lead structure (compound 6), exhibiting substantially enhanced selectivity toward eukaryotic versus prokaryotic rib...

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Detalles Bibliográficos
Autores principales: Guchhait, Sandip, Khononov, Alina, Pieńko, Tomasz, Belakhov, Valery, Baasov, Timor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258827/
https://www.ncbi.nlm.nih.gov/pubmed/37312846
http://dx.doi.org/10.1021/acsmedchemlett.3c00089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258827/
https://www.ncbi.nlm.nih.gov/pubmed/37312846
http://dx.doi.org/10.1021/acsmedchemlett.3c00089

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