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Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases
[Image: see text] New derivatives of aminoglycosides with a side chain 1,2-aminoalcohol at the 5” position of ring III were designed, synthesized, and biologically evaluated. The novel lead structure (compound 6), exhibiting substantially enhanced selectivity toward eukaryotic versus prokaryotic rib...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258827/ https://www.ncbi.nlm.nih.gov/pubmed/37312846 http://dx.doi.org/10.1021/acsmedchemlett.3c00089 |