Alzheimer’s Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology

BACKGROUND: The tau protein phosphorylated at Thr181 (p-tau181) in cerebrospinal fluid and blood is a sensitive biomarker for Alzheimer’s disease (AD). Increased p-tau181 levels correlate well with amyloid-β (Aβ) pathology and precede neurofibrillary tangle formation in the early stage of AD; howeve...

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Detalles Bibliográficos
Autores principales: Hirota, Yu, Sakakibara, Yasufumi, Takei, Kimi, Nishijima, Risa, Sekiya, Michiko, Iijima, Koichi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258885/
https://www.ncbi.nlm.nih.gov/pubmed/37212118
http://dx.doi.org/10.3233/JAD-230121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258885/
https://www.ncbi.nlm.nih.gov/pubmed/37212118
http://dx.doi.org/10.3233/JAD-230121

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