Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4(+) T cells specific for the epidermal autoantigen desmoglein 3

Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4(+) T cells expressing a transgenic T cell receptor specific for desmoglein 3 (Dsg3), which is the target antigen of the autoimmune bullous disease pemphigus vulgaris, to examine how...

Descripción completa

Detalles Bibliográficos
Autores principales: Iriki, Hisato, Mukai, Miho, Asahina, Yasuhiko, Kubo, Yoko, Ito, Hiromi, Amagai, Masayuki, Takahashi, Hayato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259059/
https://www.ncbi.nlm.nih.gov/pubmed/37308897
http://dx.doi.org/10.1186/s12979-023-00353-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259059/
https://www.ncbi.nlm.nih.gov/pubmed/37308897
http://dx.doi.org/10.1186/s12979-023-00353-9

Ejemplares similares