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Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4(+) T cells specific for the epidermal autoantigen desmoglein 3
Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4(+) T cells expressing a transgenic T cell receptor specific for desmoglein 3 (Dsg3), which is the target antigen of the autoimmune bullous disease pemphigus vulgaris, to examine how...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259059/ https://www.ncbi.nlm.nih.gov/pubmed/37308897 http://dx.doi.org/10.1186/s12979-023-00353-9 |