Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication

The papain-like protease (PLpro) plays a critical role in SARS-CoV-2 (SCoV-2) pathogenesis and is essential for viral replication and for allowing the virus to evade the host immune response. Inhibitors of PLpro have great therapeutic potential, however, developing them has been challenging due to P...

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Detalles Bibliográficos
Autores principales: Bajaj, Teena, Wehri, Eddie, Suryawanshi, Rahul K., King, Elizabeth, Pardeshi, Kundan Singh, Behrouzi, Kamyar, Khodabakhshi, Zahra, Schulze-Gahmen, Ursula, Kumar, G. Renuka, Mofrad, Mohammad R. K., Nomura, Daniel K., Ott, Melanie, Schaletzky, Julia, Murthy, Niren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259201/
https://www.ncbi.nlm.nih.gov/pubmed/37312993
http://dx.doi.org/10.1039/d3ra01915b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259201/
https://www.ncbi.nlm.nih.gov/pubmed/37312993
http://dx.doi.org/10.1039/d3ra01915b

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