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Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication
The papain-like protease (PLpro) plays a critical role in SARS-CoV-2 (SCoV-2) pathogenesis and is essential for viral replication and for allowing the virus to evade the host immune response. Inhibitors of PLpro have great therapeutic potential, however, developing them has been challenging due to P...
Autores principales: | Bajaj, Teena, Wehri, Eddie, Suryawanshi, Rahul K., King, Elizabeth, Pardeshi, Kundan Singh, Behrouzi, Kamyar, Khodabakhshi, Zahra, Schulze-Gahmen, Ursula, Kumar, G. Renuka, Mofrad, Mohammad R. K., Nomura, Daniel K., Ott, Melanie, Schaletzky, Julia, Murthy, Niren |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259201/ https://www.ncbi.nlm.nih.gov/pubmed/37312993 http://dx.doi.org/10.1039/d3ra01915b |
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