The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis

INTRODUCTION: To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA). METHODS: SNP genotyping was performed using genomic DNA isolated fro...

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Detalles Bibliográficos
Autores principales: Roszkiewicz, Justyna, Michałek, Dominika, Ryk, Aleksandra, Szmyd, Bartosz, Smolewska, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259383/
https://www.ncbi.nlm.nih.gov/pubmed/37313208
http://dx.doi.org/10.5114/aoms/163259
Descripción
Sumario:INTRODUCTION: To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA). METHODS: SNP genotyping was performed using genomic DNA isolated from peripheral blood samples. RESULTS: Patients with MTHFR rs1801133 CT/TT variant had higher values of inflammatory markers, number of joints with active arthritis, and JADAS-71 value at the baseline of MTX treatment. Children with MTRR rs1801394 AG/AA variant presented higher inflammatory marker values at JIA diagnosis. CONCLUSIONS: MTHFR rs1801133 and MTRR rs1801394 polymorphisms are associated with higher disease activity at the moment of JIA diagnosis.

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