The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis

INTRODUCTION: To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA). METHODS: SNP genotyping was performed using genomic DNA isolated fro...

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Detalles Bibliográficos
Autores principales: Roszkiewicz, Justyna, Michałek, Dominika, Ryk, Aleksandra, Szmyd, Bartosz, Smolewska, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259383/
https://www.ncbi.nlm.nih.gov/pubmed/37313208
http://dx.doi.org/10.5114/aoms/163259
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author Roszkiewicz, Justyna
Michałek, Dominika
Ryk, Aleksandra
Szmyd, Bartosz
Smolewska, Elżbieta
author_facet Roszkiewicz, Justyna
Michałek, Dominika
Ryk, Aleksandra
Szmyd, Bartosz
Smolewska, Elżbieta
author_sort Roszkiewicz, Justyna
collection PubMed
description INTRODUCTION: To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA). METHODS: SNP genotyping was performed using genomic DNA isolated from peripheral blood samples. RESULTS: Patients with MTHFR rs1801133 CT/TT variant had higher values of inflammatory markers, number of joints with active arthritis, and JADAS-71 value at the baseline of MTX treatment. Children with MTRR rs1801394 AG/AA variant presented higher inflammatory marker values at JIA diagnosis. CONCLUSIONS: MTHFR rs1801133 and MTRR rs1801394 polymorphisms are associated with higher disease activity at the moment of JIA diagnosis.
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spelling pubmed-102593832023-06-13 The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis Roszkiewicz, Justyna Michałek, Dominika Ryk, Aleksandra Szmyd, Bartosz Smolewska, Elżbieta Arch Med Sci Research Letter INTRODUCTION: To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA). METHODS: SNP genotyping was performed using genomic DNA isolated from peripheral blood samples. RESULTS: Patients with MTHFR rs1801133 CT/TT variant had higher values of inflammatory markers, number of joints with active arthritis, and JADAS-71 value at the baseline of MTX treatment. Children with MTRR rs1801394 AG/AA variant presented higher inflammatory marker values at JIA diagnosis. CONCLUSIONS: MTHFR rs1801133 and MTRR rs1801394 polymorphisms are associated with higher disease activity at the moment of JIA diagnosis. Termedia Publishing House 2023-05-24 /pmc/articles/PMC10259383/ /pubmed/37313208 http://dx.doi.org/10.5114/aoms/163259 Text en Copyright: © 2023 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Roszkiewicz, Justyna
Michałek, Dominika
Ryk, Aleksandra
Szmyd, Bartosz
Smolewska, Elżbieta
The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis
title The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis
title_full The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis
title_fullStr The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis
title_full_unstemmed The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis
title_short The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis
title_sort impact of single nucleotide polymorphisms in mthfr and mtrr genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259383/
https://www.ncbi.nlm.nih.gov/pubmed/37313208
http://dx.doi.org/10.5114/aoms/163259
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