Tau polarizes an aging transcriptional signature to excitatory neurons and glia

Aging is a major risk factor for Alzheimer’s disease (AD), and cell-type vulnerability underlies its characteristic clinical manifestations. We have performed longitudinal, single-cell RNA-sequencing in Drosophila with pan-neuronal expression of human tau, which forms AD neurofibrillary tangle patho...

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Detalles Bibliográficos
Autores principales: Wu, Timothy, Deger, Jennifer M, Ye, Hui, Guo, Caiwei, Dhindsa, Justin, Pekarek, Brandon T, Al-Ouran, Rami, Liu, Zhandong, Al-Ramahi, Ismael, Botas, Juan, Shulman, Joshua M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259480/
https://www.ncbi.nlm.nih.gov/pubmed/37219079
http://dx.doi.org/10.7554/eLife.85251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259480/
https://www.ncbi.nlm.nih.gov/pubmed/37219079
http://dx.doi.org/10.7554/eLife.85251

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