The CD73 immune checkpoint promotes tumor cell metabolic fitness

CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials. Yet, the tumor cell-intrinsic impact of CD73 remain largely uncharacterized....

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Detalles Bibliográficos
Autores principales: Allard, David, Cousineau, Isabelle, Ma, Eric H, Allard, Bertrand, Bareche, Yacine, Fleury, Hubert, Stagg, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259490/
https://www.ncbi.nlm.nih.gov/pubmed/37261423
http://dx.doi.org/10.7554/eLife.84508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259490/
https://www.ncbi.nlm.nih.gov/pubmed/37261423
http://dx.doi.org/10.7554/eLife.84508

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