Unraveling the influences of sequence and position on yeast uORF activity using massively parallel reporter systems and machine learning

Upstream open-reading frames (uORFs) are potent cis-acting regulators of mRNA translation and nonsense-mediated decay (NMD). While both AUG- and non-AUG initiated uORFs are ubiquitous in ribosome profiling studies, few uORFs have been experimentally tested. Consequently, the relative influences of s...

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Detalles Bibliográficos
Autores principales: May, Gemma E, Akirtava, Christina, Agar-Johnson, Matthew, Micic, Jelena, Woolford, John, McManus, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259493/
https://www.ncbi.nlm.nih.gov/pubmed/37227054
http://dx.doi.org/10.7554/eLife.69611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259493/
https://www.ncbi.nlm.nih.gov/pubmed/37227054
http://dx.doi.org/10.7554/eLife.69611

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