Leader peptide or pro-segment mutants of renin are misrouted to mitochondria in autosomal dominant tubulointerstitial kidney disease

Autosomal dominant tubulointerstitial kidney disease (ADTKD), a rare genetic disorder characterised by progressive chronic kidney disease, is caused by mutations in different genes, including REN, encoding renin. Renin is a secreted protease composed of three domains: the leader peptide that allows...

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Detalles Bibliográficos
Autores principales: Schaeffer, Céline, De Fusco, Maurizio, Pasqualetto, Elena, Scolari, Caterina, Izzi, Claudia, Scolari, Francesco, Rampoldi, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259838/
https://www.ncbi.nlm.nih.gov/pubmed/37283036
http://dx.doi.org/10.1242/dmm.049963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259838/
https://www.ncbi.nlm.nih.gov/pubmed/37283036
http://dx.doi.org/10.1242/dmm.049963

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