HGG-14. RAS PATHWAY MEDIATED REGULATION OF HISTONE METHYLTRANSFERASE AND TUMOR SUPPRESSOR SETD2 IN PEDIATRIC HIGH GRADE GLIOMA

BACKGROUND: Pediatric High-Grade Gliomas (pHGG) are a significant cause of cancer-associated deaths in children. Hemispheric pHGG have frequent loss of the NF1 tumor suppressor (15%) causing aberrant RAS pathway activation. Intriguingly, loss of SETD2, a H3K36 methyltransferase, significantly co-occ...

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Detalles Bibliográficos
Autores principales: Liou, Angela, Moran, Deborah, Dougherty, Jacquelyn, Harvey, Kyra, Brosius, Stephanie, Labella, Kay, De Raedt, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: High Grade Glioma/Gliomatosis Cerebri - HGG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259893/
http://dx.doi.org/10.1093/neuonc/noad073.163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259893/
http://dx.doi.org/10.1093/neuonc/noad073.163

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