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HGG-18. SINGLE CELL RNA-SEQ ANALYSIS OF PEDIATRIC HIGH-GRADE GLIOMA PATIENT SAMPLES IDENTIFIES COMMON GLIAL AND IMMUNE CELL TYPES THAT HELP TO EXPLAIN HETEROGENEITY AND TUMORIGENESIS

BACKGROUND: Pediatric high-grade gliomas (PHGG) are aggressive, undifferentiated central nervous system (CNS) tumors. PHGG comprises subtypes that differ phenotypically, histologically and by cellular composition. Despite intensive research, overall survival rates have remained for decades around 2%...

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Detalles Bibliográficos
Autores principales: DeSisto, John, Donson, Andrew, Griesinger, Andrea, Fu, Rui, Levy, Jean Mulcahy, Foreman, Nicholas, Vibhakar, Rajeev, Green, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259924/
http://dx.doi.org/10.1093/neuonc/noad073.167