BIOL-18. NEWLY DEVELOPED REPLICATION REPAIR DEFICIENT (RRD) MOUSE MODELS PROVIDE INSIGHTS INTO MEDULLOBLASTOMA/GLIOMAGENESIS AND RESPONSE TO IMMUNOTHERAPY

Replication Repair Deficiency (RRD), caused by germline monoallelic (Lynch Syndrome) or biallelic (Constitutional Mismatch Repair Deficiency, CMMRD) mutations in MMR genes, is present in 5-10% of glioblastomas in children, adolescents, and young adults. RRD glioblastomas are chemoradiation-resistant...

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Detalles Bibliográficos
Autores principales: Aamir, Zoya, Galati, Melissa, Gattoni, Emma, Crump, Owen, Nunes, Nuno M, Das, Anirban, Fernandez, Nicholas R, Wong, Angel K Q, Fortin, Jerome, Stengs, Lucie, Bianchi, Vanessa, Edwards, Melissa, Negm, Logine, Chung, Jiil, Malkin, David, Egan, Sean, Hawkins, Cynthia, Tabori, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Basic Biology/Stem Cells/Models - BIOL
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259929/
http://dx.doi.org/10.1093/neuonc/noad073.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259929/
http://dx.doi.org/10.1093/neuonc/noad073.037

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