IMMU-15. PHASE I TRIAL OF GD2.CART-CELLS AUGMENTED WITH A CONSTITUTIVELY ACTIVE INTERLEUKIN-7 RECEPTOR (C7R) FOR TREATMENT OF HIGH-GRADE PEDIATRIC CNS TUMORS

BACKGROUND: Treatment of pediatric CNS tumors with T-cells modified with chimeric antigen receptors (CARTs) provides an innovative approach. We employ GD2-directed CART-cells (GD2.CARTs) modified to express a constitutively active interleukin-7 receptor (C7R) to increase GD2.CART survival and functi...

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Detalles Bibliográficos
Autores principales: Lin, Frank, Stuckert, Austin, Tat, Candise, Moeller, Karen, White, Mark, Ruggieri, Lucia, Zhang, Huimin, Lindsay, Holly, Baxter, Patricia, Malbari, Fatema, Aldave, Guillermo, Chintagumpala, Murali, Parsons, D Williams, Brenner, Malcolm, Heslop, Helen, Rooney, Cliona, Omer, Bilal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Immunology/Immunotherapy - IMMU
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259947/
http://dx.doi.org/10.1093/neuonc/noad073.202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259947/
http://dx.doi.org/10.1093/neuonc/noad073.202

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