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IMMU-15. PHASE I TRIAL OF GD2.CART-CELLS AUGMENTED WITH A CONSTITUTIVELY ACTIVE INTERLEUKIN-7 RECEPTOR (C7R) FOR TREATMENT OF HIGH-GRADE PEDIATRIC CNS TUMORS
BACKGROUND: Treatment of pediatric CNS tumors with T-cells modified with chimeric antigen receptors (CARTs) provides an innovative approach. We employ GD2-directed CART-cells (GD2.CARTs) modified to express a constitutively active interleukin-7 receptor (C7R) to increase GD2.CART survival and functi...
Autores principales: | Lin, Frank, Stuckert, Austin, Tat, Candise, Moeller, Karen, White, Mark, Ruggieri, Lucia, Zhang, Huimin, Lindsay, Holly, Baxter, Patricia, Malbari, Fatema, Aldave, Guillermo, Chintagumpala, Murali, Parsons, D Williams, Brenner, Malcolm, Heslop, Helen, Rooney, Cliona, Omer, Bilal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259947/ http://dx.doi.org/10.1093/neuonc/noad073.202 |
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