IMMU-01. EVALUATING THE IMPACT OF CAR DESIGN ON THE TUMOR IMMUNE MICROENVIRONMENT AND ANTI-TUMOR RESPONSE IN SYNGENEIC GLIOMA MODELS

B7-H3 CAR T-cells have limited efficacy in immunocompetent mouse models indicating a suppressive role of the tumor immune microenvironment (TIME). In this study, we set to optimize B7-H3 CAR structure and examine the effects of CAR design on brain TIME. We generated a panel of second-generation B7-H...

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Detalles Bibliográficos
Autores principales: Haydar, Dalia, Crawford, Jeremy, Chou, Ching-Heng, Guy, Cliff, Yi, Zhongzhen, Zoine, Jaquelyn, Gottschalk, Stephen, Roussel, Martine, Thomas, Paul, Krenciute, Giedre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Immunology/Immunotherapy - IMMU
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259954/
http://dx.doi.org/10.1093/neuonc/noad073.188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259954/
http://dx.doi.org/10.1093/neuonc/noad073.188

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