DIPG-13. NEW IMMUNOCOMPETENT GENETICALLY-ENGINEERED MOUSE MODELS OF PEDIATRIC-TYPE DIFFUSE HIGH-GRADE GLIOMAS REVEAL MECHANISMS OF TUMOR INITIATION AND PROGRESSION

Pediatric-type diffuse high-grade gliomas (pHGGs) form a group of aggressive brain tumors with very poor prognosis. Recurrent driver mutations in TP53 and histone H3-encoding genes, most commonly H3F3A, are observed in a large proportion of these tumors. H3-K27M substitutions are particularly preval...

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Detalles Bibliográficos
Autores principales: Tian, Ruxiao, Wu, Annette, Laugesen, Eric, Mak, Tak, Fortin, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259966/
http://dx.doi.org/10.1093/neuonc/noad073.060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259966/
http://dx.doi.org/10.1093/neuonc/noad073.060

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