TRLS-14. TARGETING REPLICATIVE STRESS IN BRAIN TUMORS BY COMBINING ATR AND PARP INHIBITION

Pediatric brain tumors like MYC-amplified Medulloblastomas (MB) and Atypical Teratoid and Rhabdoid Tumors (AT/RT) continue to have poor survival rates despite recent advances in understanding tumor biology. MYC is an oncogenic transcription factor often expressed in MB and AT/RT at high levels. Whil...

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Detalles Bibliográficos
Autores principales: Sarvode, Supriya, Refaat, Alaa, DeVries, Rebekah, Pal, Anasuya, Tinkle, Christopher, Shelat, Anang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Translational Therapeutics/Clinical Trials - TRLS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259967/
http://dx.doi.org/10.1093/neuonc/noad073.317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259967/
http://dx.doi.org/10.1093/neuonc/noad073.317

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