BIOL-10. MOUSE MODELING OF PEDIATRIC MYCN GLIOMA REVEALS INTRATUMORAL HETEROGENEITY INCLUDING NEURONAL AND OLIGODENDROGLIAL LINEAGE SIGNATURES

Pediatric glioma of the subclass MYCN are highly aggressive tumors with a median age at diagnosis of 8 years and a median survival of only 14 months. Molecularly, they frequently carry (MYCN) amplifications, TP53 mutations or both of these alterations. Due to their rarity, such tumors have only rece...

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Detalles Bibliográficos
Autores principales: Schoof, Melanie, Godbole, Shweta, Albert, Thomas K, Dottermusch, Matthias, Walter, Carolin, Ballast, Annika, Qin, Nan, Olivera, Marlene Baca, Göbel, Carolin, Neyazi, Sina, Holdhof, Dörthe, Kresbach, Catena, Epplen, Gefion Dorothea, Thaden, Vanessa, Blattner-Johnson, Mirjam, Modemann, Franziska, Afflerbach, Ann-Kristin, Eckhardt, Alicia, Muenter, Daniel, Struve, Nina, Jones, David T W, Remke, Marc, Neumann, Julia E, Kerl, Kornelius, Schüller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Basic Biology/Stem Cells/Models - BIOL
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259972/
http://dx.doi.org/10.1093/neuonc/noad073.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259972/
http://dx.doi.org/10.1093/neuonc/noad073.029

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