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ATRT-05. DNA DAMAGE REPAIR INHIBITOR LP-184 INHIBITS CELL GROWTH IN ATRT
Atypical teratoid rhabdoid tumor (ATRT) is a rare, aggressive pediatric brain tumor. It is characterized by inactivation of SMARCB1 gene. There is currently no standard of care for treatment. LP-184 is an analog of acylfulvene. LP-184 induces cell-cycle arrest and cell apoptosis through alkylation o...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259989/ http://dx.doi.org/10.1093/neuonc/noad073.005 |