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ATRT-05. DNA DAMAGE REPAIR INHIBITOR LP-184 INHIBITS CELL GROWTH IN ATRT

Atypical teratoid rhabdoid tumor (ATRT) is a rare, aggressive pediatric brain tumor. It is characterized by inactivation of SMARCB1 gene. There is currently no standard of care for treatment. LP-184 is an analog of acylfulvene. LP-184 induces cell-cycle arrest and cell apoptosis through alkylation o...

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Detalles Bibliográficos
Autores principales:	Kwon, Hyuk Jean, Shah, Nisha, Musa, Istabraq, Raabe, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Final Category: ATRT/Embryonal/ETMR - ATRT
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259989/ http://dx.doi.org/10.1093/neuonc/noad073.005

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