DIPG-37. TRANSCRIPTIONAL, EPIGENETIC, AND IMMUNOLOGICAL FEATURES OF PAEDIATRIC-TYPE H3 K27-ALTERED DIFFUSE MIDLINE GLIOMAS ORIGINATING FROM DIFFERENT BRAIN LOCATIONS

Diffuse midline gliomas (DMG) are highly aggressive brain tumours predominantly affecting young children. The main oncogenic driver is the substitution of lysine 27 to methionine (K27M) in histone 3 (H3) or overexpression of EZHIP resulting in global loss of H3K27me3. Recent single-cell (epi-)genomi...

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Detalles Bibliográficos
Autores principales: Grabovska, Yura, Mackay, Alan, Pereira, Rita, Sejdiu, Drenusha, Burford, Anna, Temelso, Sara, Clarke, Matt, Jones, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259996/
http://dx.doi.org/10.1093/neuonc/noad073.084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259996/
http://dx.doi.org/10.1093/neuonc/noad073.084

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