DIPG-47. DISCOVERING A MOLECULAR BASIS FOR VULNERABILITY OF H3K27M-DMG TO HISTONE DEACETYLASE INHIBITORS

Using two H3K27M-DMG treatment-naive preclinical models (PBT22 and PBT29), we detected a 20-fold differential response to the histone deacetylase inhibitor, Quisinostat. PBT-22 harbors mutations in H3F3A, TP53, and ASXL2, while PBT-29 has mutations in H3F3A, TP53, PIK3CA and FGFR1. Acetylation and d...

Descripción completa

Detalles Bibliográficos
Autores principales: Paine, Danyelle, Hao, Yue, Tang, Nanyun, Biery, Matt, Vitanza, Nicholas, Berens, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260008/
http://dx.doi.org/10.1093/neuonc/noad073.094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260008/
http://dx.doi.org/10.1093/neuonc/noad073.094

Ejemplares similares