DIPG-42. MAPPING THE DNA METHYLATION LANDSCAPE OF DIPG REVEALS NOTABLE METHYLOME VARIABILITY RESPONSIVE TO PHARMACOLOGIC MODULATION

Diffuse intrinsic pontine glioma (DIPG) is an incurable pediatric brainstem tumor, driven by the H3K27M mutation leading to epigenetic dysregulation. Epigenomic analyses of DIPG have shown global loss of repressive chromatin marks accompanied by DNA hypomethylation and altered gene expression. Howev...

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Detalles Bibliográficos
Autores principales: Tetens, Ashley, Martin, Allison, Arnold, Antje, Novak, Orlandi, Idrizi, Adrian, Tryggvadottir, Rakel, Craig-Schwartz, Jordyn, Barbato, Michael, Eberhart, Charles, Resnick, Adam, Koldobskiy, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260015/
http://dx.doi.org/10.1093/neuonc/noad073.089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260015/
http://dx.doi.org/10.1093/neuonc/noad073.089

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