ATRT-09. COMBINATION OF THE PI3K INHIBITOR PAXALISIB WITH THE NUCLEOSIDE ANALOG GEMCITABINE ACTIVATES THE INTEGRATED STRESS RESPONSE AND EXTENDS SURVIVAL IN ORTHOTOPIC MODELS OF ATYPICAL TERATOID/RHABDOID TUMORS

Relapsed atypical teratoid/rhabdoid tumors (AT/RT) are a deadly disease without a known cure. The Pacific Pediatric Neuro-Oncology Consortium (PNOC) is looking for effective combination therapies for an upcoming clinical trial to better treat relapsed AT/RT. We have previously identified that AT/RT...

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Detalles Bibliográficos
Autores principales: Findlay, Tyler, Malebranche, Kristen, Geethadevi, Anupa, Eberhart, Charles, Raabe, Eric, Rubens, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: ATRT/Embryonal/ETMR - ATRT
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260017/
http://dx.doi.org/10.1093/neuonc/noad073.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260017/
http://dx.doi.org/10.1093/neuonc/noad073.009

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