The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

Class 1 cytokine receptors transmit signals through the membrane by a single transmembrane helix to an intrinsically disordered cytoplasmic domain that lacks kinase activity. While specific binding to phosphoinositides has been reported for the prolactin receptor (PRLR), the role of lipids in PRLR s...

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Detalles Bibliográficos
Autores principales: Araya-Secchi, Raul, Bugge, Katrine, Seiffert, Pernille, Petry, Amalie, Haxholm, Gitte W, Lindorff-Larsen, Kresten, Pedersen, Stine Falsig, Arleth, Lise, Kragelund, Birthe B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260020/
https://www.ncbi.nlm.nih.gov/pubmed/37232489
http://dx.doi.org/10.7554/eLife.84645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260020/
https://www.ncbi.nlm.nih.gov/pubmed/37232489
http://dx.doi.org/10.7554/eLife.84645

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