DIPG-28. IDENTIFICATION AND TARGETING OF METABOLIC VULNERABILITIES IN COMBINATION WITH PDGFRA-INHIBITION IN DIFFUSE MIDLINE GLIOMA

Diffuse midline gliomas (DMG) are driven by self-renewing, stem-like glioma cells stalled in an oligodendrocyte precursor cell (OPC)-like state that are characterized by high expression of PDGFRA. This lineage overexpression of PDGFRA, together with commonly found genomic amplifications and mutation...

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Detalles Bibliográficos
Autores principales: Neyazi, Sina, Gowda, Pruthvi S, Trissal, Maria, Fonticella, Jay-Miguel, Portero, Erika P, Haley-Read, John-Paul, Anderson, Emily P, Danial, Nika N, Filbin, Mariella G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260025/
http://dx.doi.org/10.1093/neuonc/noad073.075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260025/
http://dx.doi.org/10.1093/neuonc/noad073.075

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