BIOL-23. LOSS OF MICRORNAS COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE MYC-DEPENDENT METASTATIC MEDULLOBLASTOMA

To determine the role of microRNA regulation in brain tumor development, we incorporated a conditional allele of the microRNA processing enzyme Dicer to a glioma mouse model based on inactivation of the tumor suppressors Nf1, Trp53, and Pten using the Nestin-creERT(2) transgene. Loss of Dicer and tu...

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Detalles Bibliográficos
Autores principales: Llaguno, Sheila Alcantara, Nazarenko, Inga, Chen, Yuntao, Sun, Daochun, Gudenas, Brian, Saulnier, Olivier, Rocca, Gaspare La, Pedraza, Alicia, Burns, Dennis, Bale, Tejus, Ventura, Andrea, Northcott, Paul, Taylor, Michael, Parada, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Basic Biology/Stem Cells/Models - BIOL
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260043/
http://dx.doi.org/10.1093/neuonc/noad073.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260043/
http://dx.doi.org/10.1093/neuonc/noad073.042

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