IMMU-14. WAKING THE SLEEPING GIANT: TLR7/8 AGONIST TREATMENT STIMULATES TUMOR-ASSOCIATED MYELOID CELLS FOR MEDULLOBLASTOMA IMMUNOTHERAPY

Medulloblastomas contain large myeloid populations and we have identified a novel therapy that effectively recruits these non-tumor cells for anti-cancer effect. Medulloblastoma myeloid cells have bivalent functions, supporting tumor growth through IGF1 secretion and immunosuppression, or inhibiting...

Descripción completa

Detalles Bibliográficos
Autores principales: Pauneto, Coral Alicea, Hwang, Duhyeong, Malawsky, Daniel, Kim, Kyoungtea, Park, Christopher, Sokolsky, Marina, Gershon, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Immunology/Immunotherapy - IMMU
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260045/
http://dx.doi.org/10.1093/neuonc/noad073.201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260045/
http://dx.doi.org/10.1093/neuonc/noad073.201

Ejemplares similares