MDB-26. CDK8 IS AN ONCOGENE IN GROUP 3 MEDULLOBLASTOMA THAT IMPACTS PROTEIN TRANSLATION BY REGULATING THE TRANSCRIPTIONAL ACTIVITY OF RIBOSOMAL GENES

Medulloblastoma (MB) is one of the most common malignant childhood brain tumors. Single-cell RNA-seq analysis of human medulloblastoma patients revealed that Group 3 MBs are dominated by undifferentiated progenitor-like cells with elevated expression of ribosomal genes, suggesting that overactive ri...

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Detalles Bibliográficos
Autores principales: Wang, Dong, Veo, Bethany, Pierce, Angela, Ritz, Caitlin, Vibhakar, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Medulloblastomas - MDB
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260096/
http://dx.doi.org/10.1093/neuonc/noad073.258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260096/
http://dx.doi.org/10.1093/neuonc/noad073.258

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