DIPG-45. ELONGIN B REGULATES H3K27M CHROMATIN INCORPORATION TO PROMOTE MALIGNANCY IN DIFFUSE MIDLINE GLIOMA

Chromatin dysregulation is both a cause and consequence of aberrant RNA Polymerase II (Pol2) transcription in cancer. Some of the most striking examples of chromatin disruption in cancer include somatic mutations in genes encoding histone H3 (H3.3/H3.1K27M) observed in ~80% of diffuse midline glioma...

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Detalles Bibliográficos
Autores principales: Anastas, Jamie, Kebede, Adam, Jiao, Alan, Mimoso, Claudia, Murdaugh, Rebecca, Zee, Barry, Filbin, Mariella, Adelman, Karen, Shi, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260102/
http://dx.doi.org/10.1093/neuonc/noad073.092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260102/
http://dx.doi.org/10.1093/neuonc/noad073.092

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