EPEN-08. COMBINED PDGFR INHIBITOR AXITINIB AND RETINOID TRETINOIN DECREASES PROLIFERATION AND HIGH-RISK NEOPLASTIC SUBPOPULATION PROPORTIONS PFA EPENDYMOMA

Ependymoma (EPN) is fatal in over 50% of children and has not seen any therapeutic improvements in over 30 years. Based on data from single-cell RNA sequencing (scRNAseq) and large-scale screening of FDA-approved oncology compounds in posterior fossa group A (PFA) EPN, we hypothesized that combinati...

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Detalles Bibliográficos
Autores principales: Donson, Andrew, Grimaldo, Enrique, Riemondy, Kent, Griesinger, Andrea, Amani, Vladimir, Brunt, Breauna, Pierce, Angela, Foreman, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Ependymoma - EPEN
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260112/
http://dx.doi.org/10.1093/neuonc/noad073.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260112/
http://dx.doi.org/10.1093/neuonc/noad073.112

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