ATRT-04. TARGETING THE COREST COMPLEX HELPS REPROGRAM AT/RT’S ABNORMAL EPIGENETIC LANDSCAPE TOWARD A DIFFERENTIATION PHENOTYPE

Atypical teratoid/rhabdoid tumors (AT/RT) are deadly infantile brain tumors. Their aggressive phenotype results from a single recurring biallelic loss-of-function mutation in genes encoding components of the SWI/SNF chromatin-remodeling complex - mainly SMARCB1 and SMARCA4 in remaining tumors. Resid...

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Detalles Bibliográficos
Autores principales: Geethadevi, Anupa, Collard, Marianne, Vaidya, Nikhil, Findlay, Tyler, Malebranche, Kristen, Eberhart, Charles, Raabe, Eric, Cole, Philip, Alani, Rhoda, Rubens, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: ATRT/Embryonal/ETMR - ATRT
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260114/
http://dx.doi.org/10.1093/neuonc/noad073.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260114/
http://dx.doi.org/10.1093/neuonc/noad073.004

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