DIPG-49. A SYSTEMS BIOLOGY APPROACH TO DEFINING AND TARGETING CELL STATE-SPECIFIC MASTER REGULATOR DEPENDENCIES IN DIFFUSE MIDLINE GLIOMA

Diffuse Midline Glioma (DMG) are fatal pediatric brain tumors. We leveraged network-based methodologies to dissect the heterogeneity of DMG tumors and to discover Master Regulator (MR) proteins representing pharmacologically accessible, mechanistic determinants of molecularly distinct cell states. W...

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Detalles Bibliográficos
Autores principales: Fernández, Ester Calvo, Wang, Junqiang, Zhang, Xu, Wei, Hong-Jian, Minns, Hanna, Griffin, Aaron, Obradovic, Aleksandar, Vlahos, Lukas, Martins, Timothy, Becker, Pamela, Crawford, John, Gartrell, Robyn, Szalontay, Luca, Zacharoulis, Stergios, Zhang, Zhiguo, Wechsler-Reya, Robert, Wu, Cheng-Chia, Califano, Andrea, Pavisic, Jovana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Diffuse Intrinsic Pontine Glioma/Diffuse Midline Gliomas - DPIG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260122/
http://dx.doi.org/10.1093/neuonc/noad073.096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260122/
http://dx.doi.org/10.1093/neuonc/noad073.096

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